| 货号 | 10312-100ug |
| 描述 | F2 isoprostanes (F2-iPs) are thought to arise from the free radical-mediated peroxidation of phospholipid-bound arachidonic acid.1 They are cleaved, presumably by an unidentified phospholipase A2, and are found in the circulation and the urine. 8,12-iso-iPF2α-VI-1,5-lactone is a racemic mixture of the lactone forms of the free acid, 8,12-iso- iPF2α-VI. Previously called IPF2α-I,2 the free acid form, iPF2α-VI, is the most abundant F2-iP regioisomer measured in the urine of rats treated with CCl4 to induce lipid peroxidation.3iPF2α-VI is the only regioisomer that undergoes lactonization, and this occurs slowly in vivo or can be driven chemically.4 The less polar lactone is readily separated from the free acid forms of iPF2α.4 While the level of iPF2α-VI in plasma, urine and organs is used as a biomarker for oxidative stress,5,6 some F2-iPs also evoke significant biological effects.7 It is not known if 8,12-iso-iPF2α-VI-1,5-lactone has important physiological effects. |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lawson, J.A.,Li, H.,Rokach, J., et al. Identification of two major F2 isoprostanes, 8,12-iso- and 5-epi-8,12-iso-isoprostane F2α-VI, in human urine. The Journal of Biological Chemisty 273, 29295-29301 (1998). 2.Morrow, J.D.,Hill, K.E.,Burk, R.F., et al. A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. Proceedings of the National Academy of Sciences of the United States of America 87, 9383-9387 (1990). 3.Waugh, R.J.,Morrow, J.D.,Roberts, L.J., II, et al. Identification and relative quantitation of F2-isoprostane regioisomers formed in vivo in the rat. Free Radical Biology & Medicine 23, 943-954 (1997). 4.Adiyaman, M.,Lawson, J.A.,Khanapure, S.P., et al. Total synthesis of 17,17,18,18-d4-iPF2α-VI and quantification of iPF2α-VI in human urine by gas chromatography/mass spectrometry. Analytical Biochemistry 262, 45-56 (1998). 5.Practico, D.,Barry, O.P.,Lawson, J.A., et al. IPF2a-I: An index of lipid peroxidation in humans. Proceedings of the National Academy of Sciences of the United States of America 95, 3449-3454 (1998). 6.Van Eck, M.,Hoekstra, M.,Hildebrand, R.B., et al. Increased oxidative stress in scavenger receptor BI knockout mice with dysfunctional HDL. Arteriosclerosis, Thrombosis, and Vascular Biology 27, 2413-2419 (2007). 7.Gardi, C.,Arezzini, B.,Monaco, B., et al. F2-isoprostane receptors on hepatic stellate cells. Laboratory Investigation 88, 124-131 (2008). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥98% |
| 计算分子量 | 336.5 |
| 分子式 | C20H32O4 |
| 稳定性 | ≥ 1 year |
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