| 货号 | 11898-1mg |
| 描述 | Mitochondrial complex II (succinate dehydrogenase or succinate:ubiquinone oxidoreductase) is a functional member of the Krebs cycle and the aerobic respiratory chain that couples the oxidation of succinate to fumarate with the reduction of quinone to quinol. Atpenin A5, an antifungal antibiotic isolated from Penicillium sp. found in soil, is a highly specific ubiquinone-binding site inhibitor of succinate dehydrogenase (IC50s = 12 and 3.7 nM in nematode and mammalian mitochondria, respectively, versusIC50s > 100 μM for inhibition of complex I and complex III enzymes).1,2 Atpenin A5 has cardioprotective effects against simulated ischemia-reperfusion injury in cardiomyocytes. Several mechanisms through which this occurs, including activation of mitochondrial ATP-sensitive potassium channels or modulation of mitochondrial reactive oxygen species generation, have been proposed.3,4 |
| 别名 | Antibiotic FO-125A5; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Horsefield, R.,Yankovskaya, V.,Sexton, G., et al. Structural and computational analysis of the quinone-binding site of complex II (succinate-ubiquinone oxidoreductase): A mechanism of electron transfer and proton conduction during ubiquinone reduction. The Journal of Biological Chemisty 281(11), 7309-7316 (2006). 2.Miyadera, H.,Shiomi, K.,Ui, H., et al. Atpenins, potent and specific inhibitors of mitochondrial complex II (succinate-ubiquinone oxidoreductase). Proceedings of the National Academy of Sciences of the United States of America 100(2), 473-477 (2003). 3.Wojtovich, A.P. and Brookes, P.S. The complex II inhibitor atpenin A5 protects against cardiac ischemia-reperfusion injury via activation of mitochondrial KATP channels. Basic Research in Cardiology 104(2), 121-129 (2009). 4.Dröse, S.,Bleier, L. and Brandt, U. A common mechanism links differently acting complex II inhibitors to cardioprotection: Modulation of mitochondrial reactive oxygen species production. Molecular Pharmacology 79(5), 814-822 (2011). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 366.2 |
| 分子式 | C15H21Cl2NO5 |
| CAS号 | 119509-24-9 |
| 稳定性 | ≥ 3 years |
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