| 货号 | 5270/50 |
| 别名 | 4-Amino-7-β-D-ribofuranosyl-7H-pyrro |
| 供应商 | Tocris |
| 生物活性 | Adenosine analog; antifungal antibiotic. Inhibits RNA self-cleavage in HEK79 cells and PI 3-kinase activity in A431 epidermoid carcinoma cell membrane fractions. Also inhibits thapsigargin-induced XBP1-luciferase activation and induces apoptosis in multiple myeloma cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 291.26 |
| 分子式 | C12H13N5O4 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Riet al (2012) Identification of Toyocamycin, an agent cytotoxic for multiple myeloma cells, as a potent inhibitor of ER stress-induced XBP1 mRNA splicing. Blood.Cancer.J. 2 e79. PMID: 22852048. Yenet al (2006) Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. RNA 12 797. PMID: 16556935. Nishiokaet al (1990) Inhibition of phosphatidylinositol kinase by toyocamycin. J.Antibiot. (Tokyo). 43 1586. PMID: 2177464. |