| 货号 | 4989/50 |
| 别名 | 2-[[(2E,6E)-3,7,11-Trimethyl-2,6,10 |
| 供应商 | Tocris |
| 生物活性 | Inhibitor of active Ras proteins. Displaces active Ras from the plasma membrane; impairs downstream signaling and inhibits proliferation of endometrial carcinoma cells. Also facilitates Ras degradation. Shown to induce autophagy in several human cancer cell lines. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 358.54 |
| 分子式 | C22H30O2S |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 50 mM in 1eq. NaOH |
| 参考文献 | Faigenbaumet al (2013) Growth of poorly differentiated endometrial carcinoma is inhibited by combined action of medroxyprogesterone acetate and the Ras inhibitor Salirasib. Oncotarget 4 316. PMID: 23530112. Schmukleret al (2013) Ras inhibition enhances autophagy, which partially protects cells from death. Oncotarget 4 142. PMID: 23370967. Haklaiet al (1998) Dislodgement and accelerated degradation of Ras. Biochemistry 37 1306. PMID: 9477957. |