| 货号 | 0625/50 |
| 别名 | Pyridoxalphosphate-6-azophenyl-2',4'- |
| 供应商 | Tocris |
| 生物活性 | A non-selective P2 purinergic antagonist. Blocks recombinant P2X1, P2X2, P2X3, P2X5(IC50 = 1 - 2.6 μM), native P2Y2-like (IC50 ~ 0.9 mM), and recombinant P2Y4(IC50 ~ 15 mM) receptors. Delays onset of calcium responses to mild hypoosmotic stress in cortical slices. iso-PPADS (Cat. No. 0683) also available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 599.3 |
| 分子式 | C14H10N3Na4O12PS2 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| CAS号 | 149017-66-3 |
| 参考文献 | Thraneet al (2011) Critical role of aquaporin-4 (AQP4) in astrocytic Ca2+ signaling events elicited by cerebral edema. Proc.Natl.Acad.Sci.U S A 108 846. PMID: 21187412. Ralevic and Burnstock (1998) Receptors for purines and pyrimidines. Pharmacol.Rev. 50 413. PMID: 9755289. McLarenet al (1994) Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br.J.Pharmacol. 111 913. PMID: 8019769. Ziganshinet al (1994) Selective antagonism by PPADS at P2x-purinoceptors in rabbit isolated blood vessels. Br.J.Pharmacol. 111 923. PMID: 8019770. Lambrechtet al (1992) PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur.J.Pharmacol. 217 217. PMID: 1330591. |