| 货号 | 4124/50 |
| 别名 | 5-[[4-[2-(5-Ethyl-2-pyridinyl)-etho |
| 供应商 | Tocris |
| 生物活性 | Selective PPARγ agonist (EC50 = 0.69 μM). Thiazolidinedione (TZD) derivative and antidiabetic agent; improves insulin sensitivity. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >99 % |
| 计算分子量 | 392.9 |
| 分子式 | C19H20N2O3 |
| 可溶性/溶解性 | Soluble to 25 mM in DMSO |
| 参考文献 | Momoseet al (2002) Novel 5-substituted 2,4-thiazolidinedione and 2,4-oxazolidinedione derivatives as insulin sensitizers with antidiabetic activities. J.Med.Chem. 45 1518. PMID: 11906293. Smith (2001) Pioglitazone: mechanism of action. Int.J.Clin.Pract.Suppl. 121 13. PMID: 11594239. Sakamotoet al (2000) Activation of human peroxisome proliferator-activated receptor (PPAR) subtypes by pioglitazone. Biochem.Biophys.Res.Commun. 278 704. PMID: 11095972. Willsonet al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor γ agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665. PMID: 8576907. |