JX 06 (50 MG)
货号：
5845/50 基本售价：
4689.5 元 规格：
50 mg
产品信息
概述| 货号 | 5845/50 |
| 别名 | Bis(morpholinothiocarbonyl) disulfide |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective pyruvate dehydrogenase kinase (PDK) 1/2/3 inhibitor (IC50 values are 28, 49 and 313 nM for PDK2, PDK1 and PDK3, respectively). Exhibits selectivity for PDK1/2/3 over PDK4 and a panel of 323 other kinases. Suppresses A549 lung cancer cell proliferation in vitro. Reduces tumor volume of A549 xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 324.51 |
| 分子式 | C10H16N2O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Sunet al (2015) JX06 selectively inhibits pyruvate dehydrogenase kinase PDK1 by a covalent cysteine modification. Cancer Res. 75 4923. PMID: 26483203. |
