| 货号 | 5817/50 |
| 别名 | 4-Iodo-3-nitrobenzamide; Iniparib |
| 供应商 | Tocris |
| 生物活性 | PARP1 inhibitor. Inhibits growth of certain breast cancer cell lines in vitro. Non-selectively modifies cysteine-containing proteins in tumor cells. Inhibits ionizing radiation-induced DNA single-stranded breaks in lymphoid cell lines in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 292.03 |
| 分子式 | C7H5IN2O3 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO and to 50 mM in ethanol |
| 参考文献 | Maet al (2012) Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus. Proc.Natl.Acad.Sci.U.S.A. 109 6590. PMID: 22493268. Liuet al (2011) Iniparib nonselectively modifies cysteine-containing proteins in tumor cells and is not a bona fide PARP inhibitor. Clin.Cancer Res 18 510. PMID: 22128301. |