| 货号 | 5819/50 |
| 别名 | 4-[1-(5,6,7,8-Tetrahydro-3,5,5,8,8- |
| 供应商 | Tocris |
| 生物活性 | Potent and selective RXR agonist (EC50 values are 24, 25 and 33 nM for RXRβ, RXRγ and RXRα, respectively). Exhibits >300-fold selectivity for RXR over RAR receptors. Inhibits tumor cell invasion and migration in vitro, and inhibits metastasis and angiogenesis in mouse models. Also promotes brown adipogenic differentiation and induces brown adipogenic reprogramming from myoblasts. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 348.48 |
| 分子式 | C24H28O2 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol with gentle warming |
| 参考文献 | Nieet al (2017) Brown adipogenic reprogramming induced by a small molecule. Cell Rep. 18 624. PMID: 28099842. Yenet al (2006) A selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) inhibits angiogenesis and metastasis in solid tumours. Br.J.Cancer 94 654. PMID: 16495926. Boehmet al (1994) Synthesis and structure-activity relationships of novel retinoid X receptor-selective retinoids. J.Med.Chem. 37 2930. PMID: 8071941. |