| 货号 | 11351-5mg |
| 描述 | Verruculogen is a tremorgenic mycotoxin isolated from species of Penicillium,Aspergillus, and other fungi.1,2 It selectively inhibits the activation of Maxi-K potassium channels by charybdotoxin with a K1/2 value of 170 nM.3 Verruculogen also promotes the release of excitatory neurotransmitters when injected directly into the brain of rats and, at high doses, arrests mouse mammary carcinoma cells in M phase of the cell cycle (MIC = 12.2 μM).4,5 |
| 别名 | NA 209A;TR 1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Cole, R.J.,Kirksey, J.W.,Moore, J.H., et al. Tremorgenic toxin from Penicillium veruculosum. Appl.Microbiol. 24(2), 248-250 (1972). 2.Abad, A.,Fernández-Molina, J.V.,Bikandi, J., et al. What makes Aspergillus fumigatus a successful pathogen? Genes and molecules involved in invasive aspergillosis. Rev.Iberoam.Micol. 27(4), 155-182 (2010). 3.Knaus, H.G.,McManus, O.B.,Lee, S.H., et al. Tremorgenic indole alkaloids potently inhibit smooth muscle high-conductance calcium-activated potassium channels. Biochemistry 33(19), 5819-5828 (1994). 4.Peterson, D.W.,Bradford, H.F., and Mantle, P.G. Actions of a tremorgenic mycotoxin on amino acid transmitter release in vivo. Biochemical Pharmacology 31(17), 2807-2810 (1982). 5.Cui, C.B.,Kakeya, H.,Okada, G., et al. Novel mammalian cell cycle inhibitors, tryprostatins A, B and other diketopiperazines produced by Aspergillus fumigatus. I. Taxonomy, fermentation, isolation and biological properties. J.Antibiot.(Tokyo) 49(6), 527-533 (1996). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 511.6 |
| 分子式 | C27H33N3O7 |
| CAS号 | 12771-72-1 |
| 稳定性 | ≥ 2 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |