| 货号 | 1933/1 |
| 供应商 | Tocris |
| 生物活性 | High affinity glucagon-like peptide 1 (GLP-1) receptor agonist (Kd = 136 pM); originally isolated from Heloderma suspectum venom. Potently induces cAMP formation without stimulating amylase release in pancreatic acini. Potentiates glucose-induced insulin secretion in isolated rat islets. Protects against glutamate-induced neurotoxicity. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 4186.61 |
| 分子式 | C184H282N50O60S |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 141758-74-9 |
| 序列号 | HGEGTFTSDLSKQMEEEAVRLFIEWLKNGG (Modifications: Ser-39 = C-terminal amide) |
| 参考文献 | Perryet al (2002) Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4. J.Pharmacol.Exp.Ther. 302 881. PMID: 12183643. Gokeet al (1993) Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of insulin-secreting β-cells. J.Biol.Chem. 268 19650. PMID: 8396143. Thorenset al (1993) Cloning and functional expression of the human islet GLP-1 receptor. Demonstration that exendin-4 is an agonist and exendin-(9-39) an antagonist of the receptor. Diabetes 42 1678. PMID: 8405712. Enget al (1992) Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. J.Biol.Chem. 267 7402. PMID: 1313797. |