Copanlisib
货号：
20354-10mg 基本售价：
4620.0 元 规格：
10 mg
产品信息
概述| 货号 | 20354-10mg |
| 描述 | Copanlisib is an inhibitor of class I phosphoinositide 3-kinase (PI3K) isoforms (IC50s = 0.5, 3.7, 6.4, and 0.7 nM for α, β, γ, and δ, respectively).1 It is weakly active or inactive against numerous other kinases. Copanlisib is effective in vivo when administered intravenously, inhibiting PI3K signaling and inducing tumor regression via apoptosis in xenograft tumors in mice.1,2 |
| 别名 | BAY 80-6946; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Liu, N.,Rowley, B.R.,Bull, C.O., et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models. Mol. Cancer Ther. 12(11), 2319-2330 (2013).
2.Will, M.,Qin, A.C.R.,Toy, W., et al. Rapid induction of apoptosis by PI3K inhibitors is dependent upon their transient inhibition of RAS-ERK signaling. Cancer Discov. 4(3), 334-347 (2014).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 480.5 |
| 分子式 | C23H28N8O4 |
| CAS号 | 1032568-63-0 |
| 稳定性 | ≥ 2 years |
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