| 货号 | 15139-50ug |
| 描述 | Stimulator of Interferon Genes (STING) is a component of the innate immune response. STING binds to cyclic dinucleotides, which are bacterial second messengers.1 Recognition of cyclic-di-GMP (c-di-GMP), c-di-AMP, or c-GMP-AMP leads to activation of NF-κB and transcription of immunomodulatory genes, including type I interferon (IFN).2,3,4 Loss of STING regulation contributes to autoimmune disorders through increased IFN activity.5 The gene for STING is mutated in the mouse strain Goldenticket, which consequently lacks a type I IFN response to Listeriainfection.6 Activation of STING by the flavonoid 5,6-dimethylxanthenone-4-acetic acid (DMXAA; Item No. 14617) has been shown to kill solid tumors in mice, but the binding site of DMXAA is not conserved in human STING.7,8 |
| 别名 | ERIS;MITA;MPYS;Stimulator of Interferon Genes;TMEM173; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Burdette, D.L.,Monroe, K.M.,Sotelo-Troha, K., et al. STING is a direct innate immune sensor of cyclic-di-GMP. Nature 478(7370), 515-518 (2011). 2.Sun, L.,Wu, J.,Du, F., et al. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science 339(6121), 786-791 (2013). 3.Wu, J.,Sun, L.,Chen, X., et al. Cyclic GMP-AMP is an endogenous second messenger in innate immune signaling by cytosolic DNA. Science 339(6121), 826-830 (2013). 4.Konno, H.,Konno, K. and Barber, G.N. Cyclic dinucleotides trigger ULK1 (ATG1) phosphorylation of STING to prevent sustained innate immune signaling. Cell 155(3), 688-698 (2013). 5.Gall, A.,Treuting, P.,Elkon, K.B., et al. Autoimmunity initiates in non-hematopoietic cells and progresses via lymphocytes in an interferon-dependent autoimmune disease. Immunity 36(1), 120-131 (2012). 6.Sauer, J.D.,Sotelo-Troha, K.,von Moltke, J., et al. The N-ethyl-N-nitrosourea-induced Goldenticket mouse mutant reveals an essential function of sting in the in vivo interferon response to Listeria monocytogenes and cyclic dinucleotides. Infection and Immunity 79(2), 688-694 (2011). 7.Kim, S.,Li, L.,Maliga, Z., et al. Anticancer flavonoids are mouse-selective STING agonists. ACS Chemical Biology (2013). 8.Gao, P.,Ascano, M.,Zillinger, T., et al. Structure-function analysis of STING activation by c[G(2,5)pA(3,5)p] and targeting by antiviral DMXAA. Cell 154(4), 748-762 (2013). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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