Amlodipine
货号：
14838-5g 基本售价：
4620.0 元 规格：
5 g
产品信息
概述| 货号 | 14838-5g |
| 描述 | Amlodipine is a dihydropyridine L-type calcium channel blocker that selectively inhibits calcium influx in cardiac and vascular smooth muscle.1 Acting as a vasodilator, amlodipine reduces blood pressure by relaxing the smooth muscle in the arterial wall, decreasing total peripheral resistance. It inhibits calcium-induced contractions in depolarized rat aorta with an IC50 value of 1.9 nM, displaying a slow rate of association and dissociation in isolated vascular and cardiac tissues.1 When used in combination with the angiotensin receptor blocker olmesartan, amlopidine has been shown to potentiate antihypertensive activity.2 Amlodipine also demonstrates actions independent of L-type calcium channel blockade by regulating membrane fluidity and cholesterol deposition, stimulating nitric oxide production, acting as an antioxidant, and regulating matrix deposition.3 |
| 别名 | Intervask;Pelmec; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Burges, R.A.,Gardiner, D.G.,Gwilt, M., et al. Calcium channel blocking properties of amlodipine in vascular smooth muscle and cardiac muscle in vitro: Evidence for voltage modulation of vascular dihydropyridine receptors. Journal of Cardiovascular Pharmacology 9(1), 110-119 (1987).
2.Ferrario, C.M. and Smith, R.D. Role of olmesartan in combination therapy in blood pressure control and vascular function. Vascular Health and Risk Management 6, 701-709 (2010).
3.Mason, R.P.,Marche, P. and Hintze, T.H. Novel vascular biology of third-generation L-type calcium channel antagonists: Ancillary actions of amlodipine. Arteriosclerosis, Thrombosis, and Vascular Biology 23(12), 2155-2163 (2003).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 408.9 |
| 分子式 | C20H25ClN2O5 |
| CAS号 | 88150-42-9 |
| 稳定性 | ≥ 2 years |
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