| 货号 | 1552/1 |
| 别名 | [Nphe1,Arg14,Lys15]Nociceptin-NH2 |
| 供应商 | Tocris |
| 生物活性 | Potent, selective and competitive silent antagonist for the NOP opioid receptor. Binds to NOP with high affinity (pKi = 10.24) and displays > 3000-fold selectivity over δ,μandκ opioid receptors. Antinociceptive and opposes the action of nociceptin in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1908.19 |
| 分子式 | C82H138N32O21 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | GGGFTGARKSARKRKNQ (Modifications: Gly-1 = N-(Bn)Gly, Gln-17 = C-terminal amide) |
| 参考文献 | Gavioliet al (2003) Blockade of nociceptin/orphanin FQ-NOP receptor signalling produces antidepressant-like effects: pharmacological and genetic evidences from the mouse forced swimming test. Eur.J.Neurosci. 17 1987. PMID: 12752799. Martiet al (2003) Pharmacological profiles of presynaptic nociceptin/orphanin FQ receptors modulating 5-hydroxytryptamine and noradrenaline release in the rat neocortex. Br.J.Pharmacol. 138 91. PMID: 12522077. McDonaldet al (2003) UFP-101, a high affinity antagonist for the nociceptin/orphanin FQ receptor: radioligand and GTPγ35 binding studies. Naunyn Schmiedebergs Arch.Pharmacol. 367 183. PMID: 12595960. Caloet al (2002) [Nphe1,Arg14,Lys15]Nociceptin-NH2, a novel potent and selective antagonist of the nociceptin/orphanin FQ receptor. Br.J.Pharmacol. 136 303. PMID: 12010780. |