| 货号 | 1791/1 |
| 别名 | (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of protein phosphatase types 2A (PP2A) and 4 (PP4) with IC50 values of 1.5 nM and 3 nM respectively. Also exhibits weaker inhibition of topoisomerase II (IC50 = 40 μM) and protein phosphatase type 1 (PP1) (IC50 = 131 μM) with no apparent inhibition of protein phosphatase type 2B (PP2B). Active in vivo. Originally identified as an antitumor antibiotic from Streptomyces pulveraceous. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 452.37 |
| 分子式 | C208H336N74O44S3 |
| 可溶性/溶解性 | Soluble to 100 mM in water |
| 参考文献 | Hastie and Cohen (1998) Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. FEBS Lett. 431 357. PMID: 9714542. Walshet al (1997) Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. FEBS Lett. 416 230. PMID: 9373158. Tunacet al (1983) Novel antitumor agents CI-920, PD 113,270 and PD 113,271. I. Taxonomy, fermentation and biological properties. J.Antibiot. 36 1595. PMID: 6689323. |