| 货号 | 5571/100U |
| 供应商 | Tocris |
| 生物活性 | High affinity, selective KCa2.2 (SK2) channel blocker (Kd = 3.8 nM). Exhibits >200-fold selectivity for KCa2.2 over KCa2.1, KCa2.3, KCa3.1, IK, Kv and Kir2.1. Increases theta-burst responses and increases LTP in rat hippocampal slices in vitro. Convulsive in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3392.06 |
| 分子式 | C141H236N46O |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| 序列号 | AFCNLRXCQLSCRSLGLLGKCIGDKCECVK (Modifications: X = Dab, Disulfide bridges: 3-21, 8-26, 12-28, His-31 = C-terminal amide) |
| 参考文献 | Kasumuet al (2012) Selective positive modulator of calcium-activated potassium channels exerts beneficial effects in a mouse model of spinocerebellar ataxia type 2. Chem.Biol. 19 1340. PMID: 23102227. Kramaret al (2004) A novel mechanism for the facilitation of theta-induced long-term potentiation by brain-derived neurotrophic factor. J.Neurosci. 24 5151. PMID: 15175384. Shakkottaiet al (2001) Design and characterization of a highly selective peptide inhibitor of the small conductance calcium-activated K+ channel, SkCa2. J.Biol.Chem. 276 43145. PMID: 11527975. |