| 货号 | 2792/100U |
| 别名 | Cyclo[(3R)-3-(4-hydroxyphenyl)-β-ala |
| 供应商 | Tocris |
| 生物活性 | Rapidly stabilizes pre-formed actin filaments and inhibits their disassembly in vitro. Also induces polymerization of actin monomers into F-actin in vivo. Shown to bind to F-actin competitively with phalloidin (Cat. No. 4535) (Kd ~ 15 nM). Exhibits antifungal and antiproliferative effects (IC50 = 35 nM for antiproliferative activity in PC3 cells). Cell permeable. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 709.67 |
| 分子式 | C36H45BrN4O6 |
| 可溶性/溶解性 | Soluble to 2 mg/ml in DMSO |
| 参考文献 | Bubbet al (2000) Effects of jasplakinolide on the kinetics of actin polymerization. J.Biol.Chem. 275 5163. PMID: 10671562. Cramer (1999) Role of actin-filament disassembly in lamellipodium protrusion in motile cells revealed using the drug jasplakinolide. Curr.Biol. 9 1095. PMID: 10531004. Bubbet al (1995) Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J.Biol.Chem. 269 14869. PMID: 8195116. |