| 货号 | 1832/1 |
| 供应商 | Tocris |
| 生物活性 | Highly potent melanocortin MC4 receptor antagonist (Ki values are 0.29, 18.6, 5.45 and 3.29 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake, and blocks α-MSH- and MTII-induced hypotension and bradycardia in rats, following central administration in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1266.5 |
| 分子式 | C58H79N19O10S2 |
| 可溶性/溶解性 | Soluble to 0.50 mg/ml in water |
| CAS号 | 212370-59-7 |
| 序列号 | CXRHXRWGC (Modifications: Cys-1 = N-terminal Ac, X-2 = Nle, X-5 = Nal, Cys-9 = C-terminal amide, Disulfide bridge between 1 - 9) |
| 参考文献 | Jonssonet al (2002) Food conversion is transiently affected during 4-week chronic administration of melanocortin agonist and antagonist in rats. J.Endocrinol. 173 517. PMID: 12065241. Jonssonet al (2001) Melanocortin receptor agonist transiently increases oxygen consumption in rats. Neuroreport 12 3703. PMID: 11726778. Kasket al (1998) Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitroandin vivo. Endocrinology 139 5006. PMID: 9832440. |