| 货号 | 1831/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective melanocortin MC4 receptor antagonist (Ki values are 3.16, 108, 54.4 and 694 nM for cloned human MC4, MC1, MC3 and MC5 receptors respectively). Increases food intake in rats and nociception in mice following central administration in vivo. Also inhibits IL-1β-induced Fos expression in the paraventricular hypothalamus. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1563.77 |
| 分子式 | C71H94N20O17S2 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in water |
| CAS号 | 207678-81-7 |
| 序列号 | CEHXRWGCPPKD (Modifications: Cys-1 = N-terminal Ac, X = 2-Nal, Asp-12 = C-terminal amide, Disulfide bridge between 1 - 8) |
| 参考文献 | Whitaker and Reye (2008) Central blockade of melanocortin receptors attenuates the metabolic and locomotor responses to peripheral interleukin-1β administration. Neuropharmacology 54 509. PMID: 18082228. Bellasioet al (2003) Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur.J.Pharmacol. 482 127. PMID: 14660013. Schiothet al (1998) Discovery of novel melanocortin4 receptor selective MSH analogues. Br.J.Pharmacol. 124 75. PMID: 9630346. |