| 货号 | 3502/100U |
| 别名 | (1S,3S,7S,10R,11S,12S,16R)-7,11-Dih |
| 供应商 | Tocris |
| 生物活性 | Microtubule stabilization agent that promotes tubulin polymerization and induces G2-M cell cycle arrest (EC50 = 32 nM in HeLa cells). Inhibits proliferation of human carcinoma cell lines in vitro, including MDR cells overexpressing the P-glycoprotein efflux pump. Exhibits potent cytotoxicity in MCF-7 and A549 cells (EC50 values are 0.3 and 2.7 nM respectively). Inhibits growth of HCT-15 tumors in mice in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 507.68 |
| 分子式 | C27H41NO6S |
| 可溶性/溶解性 | Soluble to 10 mM in DMSO |
| 参考文献 | Narviet al (2013) Altered TUBB3 expression contributes to the epothilone response of mitotic cells. Br.J.Cancer 108 82. PMID: 23321512. O'Reillyet al (2008) Pharmacokinetic profile of the microtubule stabilizer patupilone in tumor-bearing rodents and comparison of anti-cancer activity with other MTS in vitro and in vivo. Cancer Chemother.Pharmacol. 62 1045. PMID: 18301895. Altmannet al (2000) Epothilones and related structures - a new class of microtubule inhibitors with potent in vivo antitumor activity. Biochim.Biophys.Acta 1470 M79. PMID: 10799747. |