| 货号 | 1793/1 |
| 供应商 | Tocris |
| 生物活性 | Potent and selective antagonist for the human type I interleukin-1 (IL-1) receptor (IC50 values are 8 nM, > 6.7 mM and > 200 mM for human type I, human type II and murine type I IL-1 receptors respectively). Blocks IL-1-induced expression of ICAM-1 and E-selectin in HUVECs and IL-1β induction of IL-8 in human dermal fibroblasts. Reduces IL-1β-induced IL-6 production and exhibits anti-inflammatory activity in vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 1895.14 |
| 分子式 | C96H123N19O22 |
| 可溶性/溶解性 | Soluble to 1 mg/ml in 10% ethanol/PBS |
| CAS号 | 185413-30-3 |
| 序列号 | FEWTPGWYQXYALPL (Modifications: Phe-1 = N-terminal Ac, X - Aze, Leu-15 = C-terminal amide) |
| 参考文献 | Aimbireet al (2008) Low level laser therapy (LLLT) decreases pulmonary microvascular leakage, neutrophil influx and IL-1β levels in airway and lung from rat subjected to LPS-induced inflammation. Inflammation 31 189. PMID: 18421573. Akesonet al (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J.Biol.Chem. 271 30517. PMID: 8940020. |