| 货号 | 3587/10 |
| 别名 | (1R,2R)-2-[[4'-[[Phenylamino)carbony |
| 供应商 | Tocris |
| 生物活性 | Diacylglycerol acyltransferase 1 (DGAT-1) inhibitor (IC50 values are 7 and 24 nM at human and mouse DGAT-1 respectively) that is devoid of activity at DGAT-2, ACAT1 or ACAT2. Induces significant weight loss without altering food intake, and decreases liver and plasma triglyceride levels in vivo. Orally active. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >98 % |
| 计算分子量 | 428.48 |
| 分子式 | C25H24N2O4 |
| 可溶性/溶解性 | Soluble to 50 mM in DMSO |
| CAS号 | 959122-11-3 |
| 参考文献 | Kinget al (2010) In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia. Eur.J.Pharmacol. 637 155. PMID: 20385122. Kinget al (2009) Diacylglycerol acyltransferase 1 inhibition lowers serum triglycerides in the zucker fatty rat and the hyperlipidemic hamster. J.Pharmacol.Exp.Ther. 330 526. PMID: 19478132. Zhaoet al (2008) Validation of diacyl glycerolacyltransferase I as a novel target of obesity and dyslipidemia using a potent and selective small molecule inhibitor. J.Med.Chem. 51 380. PMID: 18183944. |