| 货号 | 13188-1KU |
| 描述 | Thrombin is the last enzyme in the clotting cascade functioning to cleave fibrinogen to fibrin and potentiates the procoagulation process by activating factors V, VIII, XI, and XIII.1 Conversely, thrombin aids the anticoagulant process by activating protein C.2 Activated protein C inhibits activated factors V and VIII ultimately down-regulating further thrombin production. Thrombin is often used as a potent platelet activator in vitro. Platelet responses to thrombin are mediated through protease-activated receptors (PARs). 3 Thrombin-mediated signaling regulates a diverse range of metabolic processes including activation of phospholipases in platelets, endothelial cells, and cardiac myocytes.4 |
| 别名 | Activated Factor II [IIa]; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Coughlin, S.R. Thrombin signalling and protease-activated receptors. Nature 407, 258-264 (2000). 2.Gibbs, C.S.,Coutré, S.E.,Tsiang, M., et al. Conversion of thrombin into an anticoagulant by protein engineering. Nature 378, 413-416 (1995). 3.Davì, G., and Patrono, C. Platelet activation and atherothrombosis. New England Journal of Medicine 357(24), 2482-2494 (2007). 4.McHowat, J., and Creer, M.H. Thrombin activates a membrane-associated calcium-independent PLA2 in ventricular myocytes. American Journal of Physiology 274, C447-C454 (1998). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| CAS号 | 2594047 |
| 稳定性 | ≥ 1 year |
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