Carbamylated Core Histones (bovine)
货号：
21076-100ug 基本售价：
4550.0 元 规格：
100 ug
产品信息
概述| 货号 | 21076-100ug |
| 描述 | Citrullination and carbamylation are two post-translational modifications that result in the generation of citrulline and homocitrulline, two highly related, non-standard amino acids. While citrullination of arginine is catalyzed by peptidylarginine deiminases (PADs), homocitrulline results from the nonenzymic reaction of cyanate with lysine. Carbamylation occurs at low levels in healthy individuals, but at higher levels in several clinical conditions such as atherosclerosis, kidney disease, and inflammation.1,2,3 Carbamylation can lead to changes in protein function, cellular function, and generation of an immune response to homocitrulline containing proteins.1,2,3 This product contains a carbamylated mixture of H1, H2A, H2B, H3, and H4 histones isolated from calf thymus. |
| 别名 | Ca-Core Histones (bovine); |
性能| 供应商 | Cayman |
| 应用文献 |
1.Shi, J.,van Veelen, P.A.,Mahler, M., et al. Carbamylation and antibodies against carbamylated proteins in autoimmunity and other pathologies. Autoimmun. Rev. 13(3), 225-230 (2014).
2.Pruijn, G.J.M. Citrullination and carbamylation in the pathophysiology of rheumatoid arthritis. Front. Immunol. 6, 192 (2015).
3.Mastrangelo, A.,Colasanti, T.,Barbati, C., et al. The role of posttranslational protein modifications in rheumatological diseases: Focus on rheumatoid arthritis. J. Immunol. Res. 2015, 712490 (2015).
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| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 稳定性 | ≥ 2 years |
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