| 货号 | 20631-50ug |
| 描述 | Proprotein convertase subtilisin kexin 9 (PCSK9) is a member of the subtilisin serine protease family with an important role in lipoprotein metabolism.1 Mutation in the PCSK9 gene is associated with autosomal dominant hypercholesterolemia, which is characterized by an increase in low density lipoprotein (LDL) cholesterol levels.2 PCSK9 overexpression in wild-type mice doubles the plasma total cholesterol, possibly through acceleration of the degradation of the LDL receptor.1,3 PCSK9 mRNA is detected in various tissues such as liver, kidney, lung, spleen, jejunum, ileum, colon, and muscle, with the highest expression in the liver.4 Human PCSK9 precursor is 692 amino acids in length with an estimated molecular weight of 74 kDa. This proprotein is self-cleaved to form a mature protein at around 63 kDa in the Golgi.5 Cayman’s PCSK9 (human recombinant) contains the mature protein (~63 kDa) as well as the cleaved portion (~16 kDa). |
| 别名 | NARC-1;Proprotein Convertase Subtilisin Kexin 9; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Maxwell, K.N.,Fisher, E.A. and Breslow, J.L. Overexpression of PCSK9 accelerates the degradation of the LDLR in a post-endoplasmic reticulum compartment. Proceedings of the National Academy of Sciences of the United States of America 102(6), 2069-2074 (2005). 2.Abifadel, M.,Varret, M.,Rabès, J.P., et al. Mutations in PCSK9 cause autosomal dominant hypercholesterolemia. Nature Genetics 34(2), 154-156 (2003). 3.Maxwell, K.N. and Breslow, J.L. Adenoviral-mediated expression of Pcsk9 in mice results in a low-density lipoprotein receptor knockout phenotype. Proceedings of the National Academy of Sciences of the United States of America 101(18), 7100-7105 (2004). 4.Seidah, N.G.,Benjannet, S.,Wickham, L., et al. The secretory proprotein convertase neural apoptosis-regulated convertase 1 (NARC-1): Liver regeneration and neuronal differentiation. Proceedings of the National Academy of Sciences of the United States of America 100(3), 928-933 (2003). 5.Maxwell, K.N. and Breslow, J.L. Proprotein convertase subtilisin kexin 9: The third locus implicated in autosomal dominant hypercholesterolemia. Current Opinion in Lipidology 16, 167-172 (2005). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 1 year |
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