Melphalan
货号：
16665-500mg 基本售价：
4550.0 元 规格：
500 mg
产品信息
概述| 货号 | 16665-500mg |
| 描述 | Melphalan is a phenylalanine derivative of mechlorethamine, belonging to the family of nitrogen mustard alkylating agents that are used for chemotherapy.1 It attaches an alkyl group to guanine bases in DNA at the 7-nitrogen of the imidazole ring, which leads to DNA interstrand and intrastrand crosslinks, cytotoxicity, and apoptosis.1 Melphalan can inhibit the growth of PC-3 prostate cancer cells with IC50 values of 0.074 or 0.77 μM for sequential dosing or single dosing, respectively.2 |
| 别名 | Alanine Nitrogen Mustard;Alkeran;NSC 8806;NSC 241286;L-Phenylalanine Mustard; |
| 是否危险品 | 是 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Vasquez, K.M. Targeting and processing of site-specific DNA interstrand crosslinks. Environ.Mol.Mutagen 51(6), 527-539 (2010).
2.Mougenot, P.,Bressolle, F.,Culine, S., et al. In vitro cytotoxic effect of melphalan and pilot phase II study in hormone-refractory prostate cancer. Anticancer Research 26(3B), 2197-2203 (2006).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 305.2 |
| 分子式 | C13H18Cl2N2O2 |
| CAS号 | 148-82-3 |
| 稳定性 | ≥ 2 years |
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