JIB-04
货号：
15338-50mg 基本售价：
4550.0 元 规格：
50 mg
产品信息
概述| 货号 | 15338-50mg |
| 描述 | JIB-04 is a pyridine hydrazone that broadly inhibits Jumonji histone demethylases (IC50s values = 230, 340, 435, 445, 855 and 1,100 nM for JARID1A, JMJD2E, JMJD2B, JMJD2A, JMJD3, and JMJD2C, respectively).1 It does not inhibit histone deacetylases and has minimal effect on the iron-containing enzymes methylcytosine dioxygenase TET1 and hypoxia-inducible factor prolyl hydroxylase 2.1 JIB-04 inhibits Jumonji demethylase activity, alters gene expression, and blocks viability of cancer cells but not in patient-matched normal cells.1,2 It also inhibits Jumonji demethylase activity in cancer cells in vivo, resulting in reduced tumor burden and prolonged survival.1 |
| 别名 | JHDM Inhibitor VII;NSC 693627; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Wang, L.,Chang, J.,Varghese, D., et al. A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth. Nat.Commun. 4, 1-24 (2013).
2.Easmon, J.,Heinisch, G.,Pürstinger, G., et al. Azinyl and diazinyl hydrazones derived from aryl N-heteroaryl ketones: Synthesis and antiproliferative activity. Journal of Medicinal Chemistry 40(26), 4420-4425 (1997).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 308.8 |
| 分子式 | C17H13ClN4 |
| CAS号 | 199596-05-9 |
| 稳定性 | ≥ 2 years |
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