Ko 143
货号：
15215-25mg 基本售价：
4550.0 元 规格：
25 mg
产品信息
概述| 货号 | 15215-25mg |
| 描述 | Breast cancer resistance protein (BCRP) is an ATP-binding cassette protein known also as ABCG2. While it normally functions as a high-capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (e.g., to mitoxantrone) in certain types of cancer.1 BCRP is abundant at the intestinal epithelium and blood-brain barrier, potentially restricting the distribution of certain drugs.2,3 Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC50s = 23 and 26 nM, respectively).2 It is much less effective at the transporters P-glycoprotein and multidrug resistance-associated protein 1, MRP1.2 Ko 143 is effective in vivo in mice.2,3 |
性能| 供应商 | Cayman |
| 应用文献 |
1.Matsuo, H.,Takada, T.,Ichida, K., et al. Common defects of ABCG2, a high-capacity urate exporter, cause gout: A function-based genetic analysis in a Japanese population. Sci.Transl.Med. 1(5), 1-9 (2009).
2.Allen, J.D.,van Loevezijn, A.,Lakhai, J.M., et al. Potent and specific inhibition of the breast cancer resistance protein multidrug transporter in vitro and in mouse intestine by a novel analogue of fumitremorgin C. Molecular Cancer Therapeutics 1(6), 417-425 (2002).
3.Wanek, T.,Kuntner, C.,Bankstahl, J.P., et al. A novel PET protocol for visualization of breast cancer resistance protein function at the blood-brain barrier. Journal of Cerebral Blood Flow and Metabolism 32(11), 2002-2011 (2012).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 469.6 |
| 分子式 | C26H35N3O5 |
| CAS号 | 461054-93-3 |
| 稳定性 | ≥ 2 years |
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