| 货号 | 14199-100ug |
| 描述 | Flap endonuclease 1 (FEN1), a RAD2 Class II nuclease, plays a crucial role in DNA repair, replication, and genomic stability.1 FEN1 removes the 5-unannealed flap during Okazaki fragment processing in lagging strand DNA synthesis.2 Removal of the DNA flap is also critical in long-patch base excision repair and regulation of recombination.3 In yeast, FEN1 mutants display sensitivity to UV irradiation, deficient chromosome segregation, and cell cycle arrest in S phase.4 Furthermore, haploinsufficiency of FEN1 in mice leads to rapid tumor progression.4 FEN1 is overexpressed in many forms of cancer, including lung, gastric, prostate, pancreatic, brain, and breast.3 |
| 别名 | FLAP Endonuclease 1;hFEN-1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Lee, B.I. and Wilson, D.M., III. The RAD2 domain of human exonuclease 1 exhibits 5 to 3 exonuclease and flap structure-specific endonuclease activities. The Journal of Biological Chemisty 274(53), 37763-37769 (1999). 2.Jagannathan, I.,Pepenella, S. and Hayes, J.J. Activity of FEN1 endonuclease on nucleosome substrates is dependent upon DNA sequence but not flap orientation. The Journal of Biological Chemisty 286(20), 17521-17529 (2011). 3.Dorjsuren, D.,Kim, D.,Maloney, D.J., et al. Complementary non-radioactive assays for investigation of human flap endonuclease 1 activity. Nucleic Acids Research 39(2), (2011). 4.Sakurai, S.,Kitano, K.,Yamaguchi, H., et al. Structural basis for recruitment of human flap endonuclease 1 to PCNA. EMBO Journal 24(4), 683-693 (2005). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 6 months |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |