| 货号 | 10784-250ug |
| 描述 | Protein Arginine Deiminases (PADs) are guanidino-modifying enzymes belonging to the amidinotransferase superfamily and are designated PAD1-4 and PAD6. PADs are calcium-dependent enzymes that catalyze the post-translational modification of target proteins by converting arginine to citrulline.1,2 The various PADs exhibit tissue specific expression and different subcellular localization.3 PAD1 is expressed in uterus and throughout the epidermis. PAD1 and PAD3 are speculated to mediate deimination of epidermal filaggrin (filament aggregation protein) and keratins, proteins involved in maintaining skin hydration.4 |
| 别名 | PADI1;PDI1;Peptidylarginine Deiminase 1;Protein Arginine Deiminase 1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vossenaar, E.R.,Zendman, A.J.,van Venrooij, W.J., et al. PAD, a growing family of citrullinating enzymes: Genes, features and involvement in disease. BioEssays 25(11), 1106-1118 (2003). 2.Shirai, H.,Blundell, T.L. and Mizuguchi, K. A novel superfamily of enzymes that catalyze the modification of guanidino groups. Trends in Biochemical Sciences 26(8), 465-468 (2001). 3.Méchin, M.C.,Enji, M.,Nachat, R., et al. The peptidylarginine deiminases expressed in human epidermis differ in their substrate specificities and subcellular locations. Cellular and Molecular Life Sciences 62(17), 1984-1995 (2005). 4.Nachat, R.,Méchin, M.C.,Takahara, H., et al. Peptidylarginine deiminase isoforms 1-3 are expressed in the epidermis and involved in the deimination of K1 and filaggrin. Journal of Investigative Dermatology 124(2), 384-393 (2005). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥95% estimated by SDS-PAGE |
| 稳定性 | ≥ 9 months |
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