| 货号 | 10011190-100U |
| 描述 | The sirtuins represent a distinct class of trichostatin A-insensitive lysyl-deacetylases (class III HDACs) and have been shown to catalyze a reaction that couples lysine deacetylation to the formation of nicotinamide and O-acetyl-ADP-ribose from NAD+ and the abstracted acetyl group.1,2,3 There are seven human sirtuins, which have been designated SIRT1-7.4 SIRT1, which is located in the nucleus, is the human sirtuin with the greatest homology to yeast Sir2 (Silent information regulator 2), regulates the activity of the tumor suppressor p53 and inhibist apoptosis.5,6,7 |
| 别名 | NAD-dependent Deacetylase 1;Silent Information Regulator 2;SIR2L1;SIR2-like Protein 1;Sirtuin 1; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Imai, S.I.,Armstrong, C.M.,Kaeberlein, M., et al. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 403, 795-800 (2000). 2.Tanner, K.G.,Landry, J.,Sternglanz, R., et al. Silent information regulator 2 family of NAD-dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proceedings of the National Academy of Sciences of the United States of America 97(26), 14178-14182 (2000). 3.Tanny, J.C. and Moazed, D. Coupling of histone deacetylation to NAD breakdown by the yeast silencing protein Sir2: Evidence for acetyl transfer from substrate to an NAD breakdown product. Proceedings of the National Academy of Sciences of the United States of America 98(2), 415-420 (2001). 4.Frye, R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochemical and Biophysical Research Communications 273, 793-798 (2000). 5.Luo, J.,Nikolaev, A.Y.,Imai, S.I., et al. Negative control of p53 by Sir2α promotes cell survival under stress. Cell 107, 137-148 (2001). 6.Vaziri, H.,Dessain, S.K.,Eaton, E.N., et al. hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase. Cell 107, 149-159 (2001). 7.Langley, E.,Pearson, M.,Faretta, M., et al. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO Journal 21(10), 2383-2396 (2002). | |
| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 稳定性 | ≥ 9 months |
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