| 货号 | 21217-1g |
| 描述 | Bestatin is a microbial-derived inhibitor of several aminopeptidases that exhibits a slow, tight-binding mechanism of action (Kis range from 1 nM to 10 µM).1,2 It inhibits the aminopeptidase activity of LTA4 hydrolase (Ki = 201 nM) and inhibits LTB4 formation by LTA4 hydrolase in human leukocytes with an IC50 value of 10 µM.3,4 |
| 别名 | NK 421;NSC 265489;Ubenimex; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Umezawa, H.,Ayoagi, T.,Suda, H., et al. Bestatin, an inhibitor of aminopeptidase B, produced by actinomycetes. J. Antibiot. (Tokyo) 2991), 97-99 (1976). 2.Scornik, O.A. and Botbol, V. Bestatin as an experimental tool in mammals. Curr. Drug Metab. 2(1), 67-85 (2001). 3.Örning, L.,Krivi, G. and Fitzpatrick, F.A. Leukotriene A4 hydrolase. The Journal of Biological Chemisty 266, 1375-1378 (1991). 4.Evans, J.F. and Kargman, S. Bestatin inhibits covalent coupling of (3H)LTA4 to human leukocyte LTA4 hydrolase. FEBS Letters 297, 139-142 (1992). | |
| 运输条件 | Wet ice in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 308.4 |
| 分子式 | C16H24N2O4 |
| CAS号 | 58970-76-6 |
| 稳定性 | ≥ 2 years |
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