Ganglioside GT1b (sodium salt)
货号：
15588-5mg 基本售价：
4455.0 元 规格：
5 mg
产品信息
概述| 货号 | 15588-5mg |
| 描述 | Gangliosides are formed from a glycosphingolipid combined with one or more sialic acids at the oligosaccharide chain. They are anchored at the outer surface of the plasma membrane where they pack densely with cholesterol to form lipid microdomains that modulate both intra- and inter-cellular signaling events. Ganglioside GT1b is a trisialoganglioside that is characterized by having two sialic residues linked to the inner galactose unit. Ganglioside GT1b has inhibitory effects towards human humoral immune responses.1 At 0.1-10 μM, it can inhibit spontaneous IgG, IgM, and IgA production by human peripheral blood mononuclear cells.1 It has also been proposed as a host cell receptor for the Merkel cell polyomavirus and as a means to enable the initiation of an infection leading to Merkel cell carcinoma.2 |
| 别名 | Ganglioside G1; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Kanda, N. and Tamaki, K. Ganglioside GT1b suppresses immunoglobulin production by human peripheral blood mononuclear cells. Immunology 96(4), 628-633 (1999).
2.Erickson, K.D.,Garcea, R.L. and Tsai, B. Ganglioside GT1b is a putative host cell receptor for the Merkel cell polyomavirus. Journal of Virology 83(19), 10275-10279 (2009).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 2195 |
| 分子式 | C95H162N5O47 • 3Na |
| CAS号 | 59247-13-1 |
| 稳定性 | ≥ 2 years |
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