| 货号 | 15260-5mg |
| 描述 | Q-VD-OPH is a broad-spectrum caspase inhibitor, blocking caspases-3, -7, -8, -9, -10, and -12 and inhibiting apoptosis when used at 10 µM.1,2 It more effectively inhibits apoptosis and is much less cytotoxic than Z-VAD-FMK (Item No. 14463) and Boc-D-FMK (Item No. 16118).1,2 Q-VD-OPH can be used in vivo, where it has been shown to prevent ischemia-reperfusion injury-induced apoptosis.3,4 This compound, by broadly inhibiting caspases, also promotes the differentiation of leukemic blasts cells, suggesting an application in differentiation therapy of certain forms of cancer.5 |
| 别名 | Quinoline-Val-Asp-Difluorophenoxymethyl Ketone; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Caserta, T.M.,Smith, A.N.,Gultice, A.D., et al. Q-VD-OPh, a broad spectrum caspase inhibitor with potent antiapoptotic properties. Apoptosis 8(4), 345-352 (2003). 2.Kuzelová, K.,Grebenová, D. and Brodská, B. Dose-dependent effects of the caspase inhibitor Q-VD-OPh on different apoptosis-related processes. Journal of Cellular Biochemistry 112(11), 3334-3342 (2011). 3.Renolleau, S.,Fau, S.,Goyenvalle, C., et al. Specific caspase inhibitor Q-VD-OPh prevents neonatal stroke in P7 rat: A role for gender. Journal of Neurochemistry 100(4), 1062-1071 (2007). 4.Braun, J.S.,Prass, K.,Dirnagl, U., et al. Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH. Experimental Neurology 206(2), 183-191 (2007). 5.Chen-Deutsch, X.,Kutner, A.,Harrison, J.S., et al. The pan-caspase inhibitor QVD has anti-leukemia effects and can interact with vitamin D analogs to increase HPK1 signaling in AML cells. Leukemia Research 36(7), 884-888 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% (mixture of tautomers) |
| 计算分子量 | 513.5 |
| 分子式 | C26H25F2N3O6 |
| CAS号 | 1135695-98-5 |
| 稳定性 | ≥ 2 years |
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