| 货号 | 4397/10 |
| 别名 | N-[4-[(3-Chloro-4-fluorophenyl)amin |
| 供应商 | Tocris |
| 生物活性 | Potent inhibitor of EGFR, ErbB2 and Abl receptor tyrosine kinases (IC50 values are 0.5-2, 19 and 41 nM, respectively). Also weak inhibitor of FLT1 and Src. Inhibits EGFR and ErbB2 autophosphorylation in vitro in NSCLC and T-47D breast cancer cell lines, respectively. Inhibits tumor growth of EGFR-overexpressing A431 and ErbB2 overexpressing BT-474 tumor xenografts in mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 507 |
| 分子式 | C27H28ClFN6O |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in 1eq. HCl |
| 参考文献 | Suzukiet al (2009) Antitumor activity of a dual epidermal growth factor receptor and ErbB2 kinase inhibitor MP-412 (AV-412) in mouse xenograft models. Cancer Sci. 100 1526. PMID: 19459856. Suzukiet al (2007) Pharmacological characterization of MP-412 (AV-412), a dual epidermal growth factor receptor and ErbB2 tyrosine kinase inhibitor. Cancer Sci. 98 1977. PMID: 17888033. |