| 货号 | 3122/500U |
| 供应商 | Tocris |
| 生物活性 | Non-competitive NMDA receptor antagonist (IC50 = 0.4 μM). Inhibits Ca2+ influx and glutamate-induced toxicity in central nervous system neurons. Exhibits age-dependent physiological effects; induces a sleep-like state in young mice and hyperactivity in older mice. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 2683.8 |
| 分子式 | C110H175N31O |
| 序列号 | GEXXYQKMLXNLRXAEVKKNA (Modifications: X = Gla, Ala-21 = C-terminal amide) |
| 参考文献 | Warderet al (2001) Amino acid determinants for NMDA receptor inhibition by conantokin-T. J.Neurochem. 77 812. PMID: 11331410. Kleinet al (1999) Inhibition of NMDA-induced currents by conantokin-G and conantokin-T in cultured embryonic murine hippocampal neurons. Neuropharmacology 38 1819. PMID: 10608277. Haacket al (1990) Conantokin-T. J.Biol.Chem. 265 6025. PMID: 2180939. |