| 货号 | 3954/10 |
| 别名 | (1R,3S)-1-[3-[[4-(2-Fluorophenyl)pi |
| 供应商 | Tocris |
| 生物活性 | Nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist. Inhibits NAADP-mediated Ca2+ release (IC50 = 6 nM); also inhibits [32P]NAADP binding (IC50 = 0.4 nM). Fluorescently labels NAADP receptors in intact cells. Stereosiomer of cis-Ned 19 (Cat. No. 3953). |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >98 % |
| 计算分子量 | 514.59 |
| 分子式 | C30H31FN4O3< |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Nayloret al (2009) Identification of a chemical probe for NAADP by virtual screening. Nat.Chem.Biol. 5 220. PMID: 19234453. Rosenet al (2009) Analogues of the nicotinic acid adenine dinucleotide phosphate (NAADP) antagonist Ned-19 indicate two binding sites on the NAADP receptor. J.Biol.Chem. 284 34930. PMID: 19826006. Thaiet al (2009) NAADP receptors mediate calcium signaling stimulated by endothelin-1 and norepinephrine in renal afferent arterioles. Am.J.Physiol.Renal Physiol. 297 F510. PMID: 19439521. |