| 货号 | 2305/50U |
| 别名 | (1R,2S,3R,6S,7S,10S,12R,15E,βR,3R)-1 |
| 供应商 | Tocris |
| 生物活性 | Selective inhibitor of protein phosphatase (PP)1 (IC50 values are 1.6 and 62 nM for PP1 and PP2 respectively). Reduces PDGF-induced vascular smooth muscle cell and mesangial cell proliferation without affecting fibronectin secretion and cellular kinase activation in vivo. Immunosuppressive agent; inhibits proliferation and induces apoptosis in activated T cells. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >95 % |
| 计算分子量 | 606.75 |
| 分子式 | C33H50O10 |
| 可溶性/溶解性 | Soluble in DMSO (supplied pre-dissolved in DMSO, 10mg/ml) |
| 参考文献 | Kimet al (2005) Effects of tautomycetin on proliferation and fibronectin secretion in vascular smooth muscle cells and glomerular mesangial cells. Transplant Proc. 37 1959. PMID: 15919517. Shimet al (2002) Immunosuppressive effects of tautomycetin in vivoandin vitro via T cell-specific apoptosis induction. Proc.Natl.Acad.Sci.USA. 99 10617. PMID: 12149481. Mitsuhashiet al (2001) Tautomycetin is a novel and specific inhibitor of serine/threonine protein phosphatase type 1, PP1. Biochem.Biophys.Res.Comm. 287 328. PMID: 11554729. |