BGC 20-1531 hydrochloride ( )
货号：
5327/10 基本售价：
4451.6 元 规格：
10 mg
产品信息
概述| 货号 | 5327/10 |
| 别名 | 4-[[4-(5-Methoxy-2-pyridinyl)phenoxy]methyl]-5-methyl-N-[(2-methylphenyl)sulfonyl]-2-furancarboxamide hydrochloride; PGN 1531 |
性能| 供应商 | Tocris |
| 生物活性 | High affinity and selective EP4 antagonist (Ki = 3 nM). Exhibits >2500-fold selectivity for EP4 over EP2 and EP3. Also selective over a range of other prostanoid receptors, ion channels, transporters and enzymes. Inhibits PGE2-induced vasodilation of middle cerebral and meningeal arteries in vitro, and carotid blood flow in vivo. Orally bioavailable. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >98 % |
| 计算分子量 | 529 |
| 分子式 | C26H24N2O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Suttonet al (2014) From virtual to clinical: The discovery of PGN-1531, a novel antagonist of the prostanoid EP4 receptor. Bioorg.Med.Chem.Lett. 24 2212. PMID: 24703233. |
