API-1 (10 MG)
货号：
3897/10 基本售价：
4451.6 元 规格：
10 mg
产品信息
概述| 货号 | 3897/10 |
| 别名 | 4-Amino-5,8-dihydro-5-oxo-8-β-D-ribofuranosyl-pyrido[2,3-d]pyrimidine-6-carboxamide |
性能| 供应商 | Tocris |
| 生物活性 | Akt/protein kinase B (PKB) inhibitor. Binds the pleckstrin homology domain of Akt and blocks Akt membrane translocation. Inhibits EGF-induced kinase activity of Akt1, Akt2 and Akt3. Induces cell growth arrest and apoptosis in human cancer cells expressing constitutively active Akt. Displays antitumor activity in vitroandin vivo. |
| 运输条件 | Blue Ice |
| 存放说明 | Ambient |
| 纯度 | >96 % |
| 计算分子量 | 337.29 |
| 分子式 | C13H15N5O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| CAS号 | 36707-00-3 |
| 参考文献 | Kimet al (2010) A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation. J.Biol.Chem. 285 8383. PMID: 20068047. |
