| 货号 | 2950/1 |
| 供应商 | Tocris |
| 生物活性 | Selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 μM). Increases secretion of amyoid β-protein (Aβ) 42, Aβ40 and Aβ42 ratio. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 计算分子量 | 3177.65 |
| 分子式 | C142H230N36O44S |
| 可溶性/溶解性 | Soluble to 5 mg/ml in water |
| CAS号 | 123714-50-1 |
| 序列号 | DPMSSTYIEELGKREVTIPPKYRELLA (Modifications: Asp-1 = N-terminal Ac, Ala-27 = C-terminal amide) |
| 参考文献 | Fiorinoet al (2007) A new cell-permeable calpain inhibitor. J.Peptide Sci. 1370. Yamazakiet al (1997) Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition. Biochem. 368377. Makiet al (1989) Inhibition of calapin by a synthetic oligopeptide corresponding to an exon of the human calpastatin gene. J.Biol.Chem. 264 18866. PMID: 2553724. |