(R)-PFI 2 hydrochloride (10 MG)
货号：
4892/10 基本售价：
4451.6 元 规格：
10 mg
产品信息
概述| 货号 | 4892/10 |
| 别名 | (1R)-1-[[3-(Trifluoromethyl)phenyl]methyl]-2-oxo-2-(1-pyrrolidinyl)ethyl]1,2,3,4-tetrahydro-6-isoquinolinesulfonamide hydrochloride |
性能| 供应商 | Tocris |
| 生物活性 | Potent and selective SETD7 histone lysine methyltransferase inhibitor (IC50 = 2 nM). Exhibits >1000-fold selectivity over DNMT1 and a panel of 18 other methyltransferases. Inhibits YAP nuclear translocation and function following activation of the Hippo signaling pathway in MCF7 cells. Negative control (S)-PFI 2 hydrochloride (Cat. No. 5400) available. |
| 运输条件 | Blue Ice |
| 存放说明 | -20℃ |
| 纯度 | >97 % |
| 计算分子量 | 535.98 |
| 分子式 | C23H25F4N3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 20 mM in ethanol with sonication |
| 参考文献 | Barsyte-Lovejoyet al (2014) (R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells. Proc.Natl.Acad.Sci.U S A 111 12853. PMID: 25136132. |
