| 货号 | 14079-1mg |
| 描述 | Glyceraldehyde 3-phosphate dehydrogenase (GAPDH), a key enzyme in carbohydrate metabolism, reversibly catalyzes the conversion of GAP to 1,3-bisphosphoglycerate and NAD+. Heptelidic acid is a sesquiterpene lactone produced by the fungus T. koningii that was shown to have antibiotic activity against anaerobic bacteria such as Bacteroides.1 It acts as an irreversible inhibitor of GAPDH that binds to the cysteine-149 residue at the active site of the enzyme (Ki = 1.6 µM).2 It can selectively induce apoptosis in high-glycolytic cancer cells by inhibiting the generation of ATP in the glycolytic pathway.3 Heptelidic acid is also a selective and competitive inhibitor of mammalian DNA polymerases β and λ as well as terminal deoxynucleotidyl transferase in family X of DNA polymerases (Kis range from 5.2-9.5 µM).4 |
| 别名 | Avocettin;BRN 5091359;FO-4443;Koningic Acid; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Endo, A.,Hasumi, K.,Sakai, K., et al. Specific inhibition of glyceraldehyde-3-phosphate dehydrogenase by koningic acid (heptelidic acid). J.Antibiot.(Tokyo) 38(7), 920-925 (1985). 2.Sakai, K.,Hasumi, K. and Endo, A. Identification of koningic acid (heptelidic acid)-modified site in rabbit muscle glyceraldehyde-3-phosphate dehydrogenase. Biochim.Biophys.Acta. 1077(2), 192-196 (1991). 3.Kumagai, S.,Narasaki, R. and Hasumi, K. Glucose-dependent active ATP depletion by koningic acid kills high-glycolytic cells. Biochem.Bioph.Res.Commun. 365(2), 362-368 (2008). 4.Yamaguchi, Y.,Manita, D.,Takeuchi, T., et al. Novel terpenoids, trichoderonic acids A and B isolated from Trichoderma virens, are selective inhibitors of family X DNA polymerases. Bioscience, Biotechnology, and Biochemistry 74(4), 793-801 (2010). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 280.3 |
| 分子式 | C15H20O5 |
| CAS号 | 57710-57-3 |
| 稳定性 | ≥ 3 years |
| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |