| 货号 | 18647-500mg |
| 描述 | Silymarin is a mixture of natural compounds isolated from milk thistle and used as a herbal remedy.1,2 (±)-Taxifolin is a flavanonol contained in silymarin, as well as other plant extracts. It is the dihydro form of quercetin (Item No. 10005169), a flavonol with antioxidant properties. (±)-Taxifolin suppresses the inflammatory response in a variety of mouse models and decreases lipid synthesis in liver cells.3,4 It regulates gene expression through the antioxidant response element in hepatic colon cancer HCT 166 cells and inhibits matrix metalloproteinases (MMP), most notably MMP-12 (IC50 = 5.7 µM).5,6 |
| 别名 | (+)-Dihydroquercetin; |
| 供应商 | Cayman |
| 应用文献 | |
| 1.Vargas-Mendoza, N.,Madrigal-Santillàn, E.,Morales-González, A., et al. Hepatoprotective effect of silymarin. World J.Hepatol. 6(3), 144-149 (2014). 2.Zholobenko, A., and Modriansky, M. Silymarin and its constituents in cardiac preconditioning. Fitoterapia 97, 122-132 (2014). 3.Gupta, M.B.,Bhalla, T.N.,Gupta, G.P., et al. Anti-inflammatory activity of taxifolin. Japanese Journal of Pharmacology 21(3), 377-382 (1971). 4.Theriault, A.,Wang, Q.,Van Iderstine, S.C., et al. Modulation of hepatic lipoprotein synthesis and secretion by taxifolin, a plant flavonoid. Journal of Lipid Research 41(12), 1969-1979 (2000). 5.Lee, S.B.,Cha, K.H.,Selenge, D., et al. The chemopreventive effect of taxifolin is exerted through ARE-dependent gene regulation. Biological and Pharmaceutical Bullentin 30(6), 1074-1079 (2015). 6.Wang, L.,Li, X.,Zhang, S., et al. Natural products as a gold mine for selective matrix metalloproteinases inhibitors. Bioorganic & Medicinal Chemistry 20(13), 4164-4171 (2012). | |
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥98% |
| 计算分子量 | 304.3 |
| 分子式 | C15H12O7 |
| CAS号 | 24198-97-8 |
| 稳定性 | ≥ 2 years |
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