UTX (human recombinant)
货号：
10774-25ug 基本售价：
4410.0 元 规格：
25 ug
产品信息
概述| 货号 | 10774-25ug |
| 描述 | Ubiquitously transcribed tetratricopeptide repeat X (UTX) gene codes for the widely-expressed UTX protein. The UTX gene is localized on the X chromosome and is a homolog of the ubiquitously transcribed mouse Y chromosome (UTY) gene. UTX gene expression has been shown to evade X-chromosome inactivation.1 The JmjC-containing UTX protein is a member of the hydroxylase family of enzymes, which are α-ketoglutarate-dependent Fe (II) oxygenases.2 UTX plays a crucial role in epigenetic regulation of gene expression by catalyzing the demethylation of tri-methylated lysine 27 on histone H3.3 UTX works in opposition to the polycomb repressive complex 2 (PRC2) group protein EZH2, playing a role in cancers with abberant H3K27 methylation. |
| 别名 | KDM6A;Ubiquitously Transcribed Tetratricopeptide Repeat X; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Greenfield, A.,Carrel, L.,Pennis, D., et al. The UTX gene escapes X inactivation in mice and humans. Human Molecular Genetics 7(4), 737-742 (1998).
2.Hübner, M.R. and Spector, D.L. Role of H3K27 demethylases Jmjd3 and UTX in transcriptional regulation. Cold Spring Harb.Symp.Quant.Biol. 75, 43-49 (2010).
3.Agger, K.,Cloos, P.A.C.,Christensen, J., et al. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Nat.Lett. 449(7163), 731-734 (2011).
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| 运输条件 | Dry ice in continental US; may vary elsewhere |
| 存放说明 | -80 |
| 纯度 | ≥70% estimated by SDS-PAGE |
| 稳定性 | ≥ 6 months |
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