Peptide YY (3-36)
货号：
16502-1mg 基本售价：
4396.0 元 规格：
1 mg
产品信息
概述| 货号 | 16502-1mg |
| 描述 | Peptide YY (PYY) is a polypeptide that is released postprandially in proportion to meal energy content by endocrine L cells in the ileum and colon in order to regulate appetite.1 PYY, along with neuropeptide Y (NPY; Item No. 15071), inhibits gastrointestinal motility and electrolyte secretion, which is thought to indicate satiety through a potent feedback signal on hypothalamic circuits.1,2 Upon release, PYY is cleaved to PYY (3-36), which is a preferred agonist at presynaptic inhibitory type 2 NPY autoreceptors (EC50 = 9.7 nM in human colon mucosa).3 PYY (3-36) has been associated with dose-dependent weight loss in various obesity models including ob/ob mice, diet-induced obese mice, and non-diabetic fatty Zucker rats.2 |
| 别名 | Pancreatic Peptide YY;Peptide Tyrosine Tyrosine; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Holzer, P.,Reichmann, F. and Farzi, A. Neuropeptide Y, peptide YY and pancreatic polypeptide in the gut-brain axis. Neuropeptides 46(6), 261-274 (2012).
2.le Roux, C.W. and Bloom, S.R. Peptide YY, appetite and food intake. Proceedings of the Nutrition Society 64(2), 213-216 (2005).
3.Cox, H.M. and Tough, I.R. Neuropeptide Y, Y1, Y2 and Y4 receptors mediate Y agonist responses in isolated human colon mucosa. British Journal of Pharmacology 135(6), 1505-1512 (2002).
|
| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 4049.6 |
| 分子式 | C180H279N53O54 |
| CAS号 | 126339-09-1 |
| 稳定性 | ≥ 2 years |
声明| 本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。 |
