| 货号 | 5325/50 |
| 别名 | 5-[[4-[2-(Methyl-2-pyridinylamino)e |
| 供应商 | Tocris |
| 生物活性 | Potent and selective PPARγ agonist (EC50 = 60 nM); exhibits no activity at PPARα and PPARβ. Promotes differentiation of pluripotent C3H10T1/2 stem cells into adipocytes. Exhibits antihyperglycemic activity in diabetic ob/ob mouse model. Antidiabetic agent. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 357.43 |
| 分子式 | C18H19N3O3 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO and to 100 mM in 1eq. HCl |
| 参考文献 | Willsonet al (1996) The structure-activity relationship between peroxisome proliferator-activated receptor gamma agonism and the antihyperglycemic activity of thiazolidinediones. J.Med.Chem. 39 665. PMID: 8576907. Lehmannet al (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J.Biol.Chem. 270 12953. PMID: 7768881. |