| 货号 | 4792/50 |
| 别名 | 2-Ethoxy-1-[[2'-(2H-tetrazol-5-yl)[1 |
| 供应商 | Tocris |
| 生物活性 | Prodrug of the angiotensin II receptor 1 (AT1) antagonist candesartan (Cat. No. 4791), which exhibits antihypertensive effects in animal models. |
| 运输条件 | Blue Ice |
| 存放说明 | 4℃ |
| 纯度 | >99 % |
| 计算分子量 | 610.66 |
| 分子式 | C33H34N6O6 |
| 可溶性/溶解性 | Soluble to 100 mM in DMSO |
| 参考文献 | Nishikawaet al (1997) Candesartan cilexetil: a review of its preclinical pharmacology. J.Hum.Hypertens. Suppl2 9. PMID: 9330999. Shiboutaet al (1993) Pharmacological profile of a highly potent and long-acting angiotensin II receptor antagonist, 2-ethoxy-1-[[2'-(1H-tetrazol-5-yl)biphenyl-4- yl]methyl]-1H-benzimidazole-7-carboxylic acid (CV-11974), and its prodrug, (±)-1-(cyclohexyloxycarbonyloxy)-ethyl 2-ethoxy-1-[[2'-(1H-tetrazol-5- yl)biphenyl-4-yl]methyl]-1H-benzimidazole-7-carboxylate (TCV-116). J.Pharmacol.Exp.Ther. 266 114. PMID: 8331552. |