MJN110
货号：
17583-25mg 基本售价：
4382.0 元 规格：
25 mg
产品信息
概述| 货号 | 17583-25mg |
| 描述 | Endocannabinoids such as 2-arachidonoyl glycerol (2-AG; Item No. 62160) and arachidonoyl ethanolamide (AEA; Item No. 90050) are biologically active lipids that are involved in a number of synaptic processes including activation of cannabinoid receptors. Monoacylglycerol lipase (MAGL) is a serine hydrolase responsible for the hydrolysis of 2-AG to arachidonic acid (Item No. 90010) and glycerol, thus terminating its biological function. MJN110 is an N-hydroxysuccinimidyl carbamate that inhibits MAGL (IC50 = 9.1 nM) and to a lesser extent ABHD6 with potent selectivity over FAAH (IC50 > 10 µM) and other brain serine hydrolases.1 It can inhibit 2-AG hydrolysis (IC50 = 2.1 nM) with no effect on AEA hydrolysis up to 50 µM.1 At 5 mg/kg, MJN110 has been shown to alleviate mechanical allodynia in a rat model of diabetic neuropathy.1 |
| 别名 | 2,5-Dioxopyrrolidin-1-yl 4-[bis(4-chlorophenyl)methyl]piperazine-1-carboxylate; |
性能| 供应商 | Cayman |
| 应用文献 |
1.Niphakis, M.J.,Cognetta, A.B., III,Chang, J.W., et al. Evalulation of NHS carbamates as a potent and selective class of endocannabinoid hydrolase inhibitors. ACS Chem.Neurosci. 4, 1322-1332 (2013).
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| 运输条件 | Room temperature in continental US; may vary elsewhere |
| 存放说明 | -20 |
| 纯度 | ≥95% |
| 计算分子量 | 462.3 |
| 分子式 | C22H21Cl2N3O4 |
| CAS号 | 1438416-21-7 |
| 稳定性 | ≥ 2 years |
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